PRF vs PRP: What’s the Difference?
PRP and PRF are both natural, regenerative treatments made from a small sample of your own blood. They sound almost the same, and they're closely related, but there are a few important differences. Here's a simple guide to how they compare and how to choose between them.
What is PRP?
PRP stands for platelet-rich plasma. A small blood sample is taken and spun at high speed in a centrifuge with an anticoagulant, which stops it from clotting. This separates out a concentrated layer of platelets, which are rich in growth factors that help the body repair and renew.
The plasma is then injected or microneedled into the skin or scalp. PRP is well established for improving skin texture, fine lines and dark circles, and for supporting thinning hair. You can read more on our PRP treatment page.
What is PRF?
PRF stands for platelet-rich fibrin. It's often described as the next generation of PRP. The blood sample is spun more gently, at a lower speed, and no anticoagulant or additives are used.
This keeps more of the natural fibrin, a protein that forms a soft scaffold, along with platelets and white blood cells. That fibrin matrix means growth factors are released more gradually, rather than all at once.
PRF vs PRP at a glance
Made from: PRP: Your own blood. PRF: Your own blood.
Additives: PRP: Anticoagulant added. PRF: None, 100% natural.
Spin speed: PRP: Higher. PRF: Lower, gentler.
Growth factor release: PRP: Faster, shorter burst. PRF: Slower and more sustained.
Fibrin and white cells: PRP: Mostly removed. PRF: Retained.
Often chosen for: PRP: Skin rejuvenation, hair thinning, microneedling. PRF: Under-eyes, fine lines, skin quality, hair thinning.
Downtime: PRP: Minimal, 1 to 3 days. PRF: Minimal, 1 to 3 days.
Which is better, PRF or PRP?
Neither is better for everyone. Both use your body's own healing factors, both are very low risk of allergy because nothing foreign is added, and both work best as a course.
PRF may suit you if you'd like a completely additive-free option, or you're treating delicate areas such as the under-eyes, where a slower, steadier release is helpful.
PRP is a well-proven choice for overall skin rejuvenation and is often combined with microneedling for texture and scarring.
For hair thinning, both can be part of a plan. We assess your scalp with a trichoscope first, so we treat the likely cause. See our hair rejuvenation page.
What happens during treatment?
1. Consultation
We talk through your concerns, medical history and goals, and check that PRF or PRP is right for you.
2. Blood sample
A small amount of blood is taken from your arm, much like a routine blood test.
3. Preparation
The sample is spun in a centrifuge to separate the PRF or PRP. This takes a few minutes.
4. Treatment
The treatment is injected or microneedled into the area. Numbing cream is used where needed, and most people find it very manageable.
Results and how many sessions
Results build gradually as your skin or scalp responds. Most people notice a difference from around three to four weeks, with the best results after a course of three treatments, four to six weeks apart. Maintenance treatments every six to twelve months help keep results going.
Who shouldn't have PRF or PRP?
They may not be suitable if you have a blood or clotting disorder, an active infection or skin condition in the area, certain chronic illnesses, or if you're pregnant or breastfeeding. We'll always check your medical history at your consultation.
PRF and PRP at AesthetiSKN
We offer both PRF and PRP at our clinics in Stoke-on-Trent and Cheadle Hulme. Every treatment is carried out by Nikita Trehan, a Physician Associate with a Level 7 Diploma in Aesthetics, so you get medical-level assessment and honest advice about which option suits you.
Not sure which is right for you?
Book a consultation and we will recommend PRF, PRP or another option based on your skin, hair and goals. Book a consultation or message us on WhatsApp.